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Based on the science of Treatment as Prevention (TasP) pioneered by Dr. Julio Montaner in 2007, we can now say with confidence that people living with HIV who are virally suppressed have no risk of transmitting HIV to their sexual partners.  Undetectable = Untransmittable (U=U) conveys this message in a prescriptive, descriptive, and empowering way.  Prevention Access Campaign, along with community activists, public health officials, and researchers, launched U=U as a message and a movement in 2016.  Join Dee Connor and Deondre Moore of Prevention Access Campaign in an exploration of the U=U supporting science, an overview of the U=U guidelines, and the best ways of communicating U=U messaging to patients.